Vdac1 translocates calcium from the cytosol to the mitochondrial intermembrane space

Stable Identifier
R-RNO-8949737
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Vdac1 translocates calcium from the cytosol to the mitochondrial intermembrane space
Vdac1 is a voltage dependent anion channel that also preferentially transports divalent calcium ions when Vdac1 is in its closed state (Gincel et al. 2001, Bathori et al. 2006, Tan and Colombini et al. 2007, Ben-Hail and Shoshan-Barmatz 2014).
Literature References
PubMed ID Title Journal Year
17617374 VDAC closure increases calcium ion flux

Tan, W, Colombini, M

Biochim. Biophys. Acta 2007
11485562 Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function

Gincel, D, Shoshan-Barmatz, V, Zaid, H

Biochem. J. 2001
16597621 Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC)

Davies, E, Garcia-Perez, C, Csordás, G, Báthori, G, Hajnóczky, G

J. Biol. Chem. 2006
24492771 Assay of Ca2+ transport by VDAC1 reconstituted into liposomes

Ben-Hail, D, Shoshan-Barmatz, V

Cold Spring Harb Protoc 2014
Participants
Input
Output
Catalyst Activity

calcium channel activity of Vdac1 [mitochondrial outer membrane]

Physical Entity
Vdac1 [mitochondrial outer membrane] (Rattus norvegicus)
Activity
calcium channel activity (GO:0005262)
Orthologous Events
VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)
Authored
May, B  (2016-11-28)
Reviewed
Drago, I  (2017-01-21)
Created
May, B  (2016-11-28)
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