Bglap gene expression is negatively regulated by Yap1

Stable Identifier
R-RNO-8937955
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Bglap gene expression is negatively regulated by Yap1
In a rat osteosarcoma cell line, used as a model of osteoblast differentiation, Runx2-mediated transcription of the Bglap gene, encoding osteocalcin, is negatively regulated when Yap1, phosphorylated on an unknown tyrosine residue by Src and/or Yes1, binds to Runx2 at the Bglap promoter (Zaidi et al. 2004).
Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Runx2:Cbfb:p-Y-Yap1:Bglap gene [nucleoplasm] (Rattus norvegicus)
Active Unit
p-Y-Yap1 [nucleoplasm]
Orthologous Events
BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-06-29)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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