Runx2:Cbfb:p-Y-Yap1 binds the Bglap gene promoter

Stable Identifier
R-RNO-8937949
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Runx2:Cbfb:p-Y-Yap1 binds the Bglap gene promoter
In rat osteosarcoma cell line, used as a model for osteoblast differentiation, the complex of Runx2, presumably associated with Cbfb, and Yap1, phosphorylated on an unknown tyrosine residue by Src and/or Yes1, binds the promoter of the Bglap (osteocalcin) gene, leading to inhibition of Runx2-mediated Bglap transcription (Zaidi et al. 2004).
Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
Participants
Input
Output
Orthologous Events
RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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