Reactome | AP-2:cargo [clathrin-coated endocytic vesicle membrane]

AP-2:cargo [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869191

Type

Complex

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Locations in the PathwayBrowser

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Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a member of

CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Inferred From

AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

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