Reactome | KIAA0319 [clathrin-coated endocytic vesicle membrane]

KIAA0319 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869092

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

P0CI71

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P0CI71

Reference Genes

BioGPS Gene:361244

ENSEMBL:ENSRNOG00000018141

ENSEMBL:ENSRNOG00000018141.7

KEGG Gene (Rattus norvegicus):361244

Monarch:361244

NCBI Gene:361244

UCSC:P0CI71

Reference Transcript

Other Identifiers

10798357

1392210_at

17719375

361244

5622684

5635220

5674113

5699511

5744096

5751552

5776808

5827481

5829680

5915241

6006303

6021240

6052644

6056296

6252993

6259785

6275722

6281772

6329361

6360008

6377923

6388524

6481114

6546506

6591186

6634095

6707948

6720194

A_44_P323765

A_64_P043361

GE1272847

GO:0005768

GO:0005769

GO:0005886

GO:0010996

GO:0023052

GO:0030154

GO:0030517

GO:0031410

GO:0033555

GO:0043226

GO:0043231

GO:0048692

GO:0048856

GO:0060391

GO:2000171

ILMN_1355131

PH_rn_0018439

PH_rn_0019586

Participates

as a component of

KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

KIAA0319 [plasma membrane]

Inferred From

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_017456093.1, NP_001183952.1

Ensembl

ENSRNOT00000024536, ENSRNOP00000024536, ENSRNOG00000018141

PRO

P0CI71

RGD

1307443

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