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SOCS-1 and SOCS-3 [cytosol]
Stable Identifier
R-RNO-877267
Type
Set [DefinedSet]
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Activation of JAK kinases (Rattus norvegicus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
Regulation of IFNG signaling (Rattus norvegicus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Transphosphorylation of JAK1 (Rattus norvegicus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
Inactivation of CSF3 (G-CSF) signaling (Rattus norvegicus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Participants
members
Socs1 [cytosol]
(Rattus norvegicus)
Socs3 [cytosol]
(Rattus norvegicus)
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Rattus norvegicus)
as an input of
SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)
Inferred From
SOCS-1 and SOCS-3 [cytosol]
(Homo sapiens)
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