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Shc1 [cytosol]
Stable Identifier
R-RNO-74680
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SHC1, Q5M824
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 in the RET complex is phosphorylated (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Tie2 Signaling (Rattus norvegicus)
Interaction of Tie2 and Shc1 (Rattus norvegicus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin-2 signaling (Rattus norvegicus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
MMPs cleave HB-EGF (Rattus norvegicus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
SHC1 events in EGFR signaling (Rattus norvegicus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
SHC1 events in ERBB2 signaling (Rattus norvegicus)
SHC1 phosphorylation by ERBB2 heterodimers (Rattus norvegicus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by ERBB4 (Rattus norvegicus)
SHC1 events in ERBB4 signaling (Rattus norvegicus)
Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)
SHC1:p-ERBB4 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)
SHC1:p-ERBB4 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
Binding of SHC1 to insulin receptor (Rattus norvegicus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Phosphorylation of SHC1 (Rattus norvegicus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Signaling by LTK (Rattus norvegicus)
Active LTK receptor binds SHC1 (Rattus norvegicus)
Active LTK:SHC1 [plasma membrane] (Rattus norvegicus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
Active LTK receptor phosphorylates SHC1 (Rattus norvegicus)
Active LTK:SHC1 [plasma membrane] (Rattus norvegicus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Rattus norvegicus)
Shc1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q5M824 Shc1
Gene Names
Shc1
Chain
chain:1-469
Reference Genes
BioGPS Gene:85385 Shc1
KEGG:rno:85385 Shc1
Monarch:85385 Shc1
NCBI Gene:85385 Shc1
UCSC:Q5M824 Shc1
Reference Transcript
RefSeq:NM_053517.2 Shc1
Participates
as an input of
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Interaction of Tie2 and Shc1 (Rattus norvegicus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)
Binding of SHC1 to insulin receptor (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)
SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)
as a component of
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Rattus norvegicus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Rattus norvegicus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Rattus norvegicus)
SHC1:p-ERBB4 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
as a candidate of
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Rattus norvegicus)
Other forms of this molecule
p-Y314-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Inferred From
SHC1 [cytosol]
(Homo sapiens)
SHC1-1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_445969.2
PRO
Q5M824
RGD
620446
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:B5DFH1 B5DFH1
0.463
2
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