Reactome | Rpl3l [cytosol]

Rpl3l [cytosol]

Stable Identifier

R-RNO-72450

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL3L, D4A9G1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3l [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A9G1

Gene Names

Rpl3l

Reference Genes

BioGPS Gene:287122 Rpl3l

ENSEMBL:ENSRNOG00000014641

ENSEMBL:ENSRNOG00000014641.8 Rpl3l

KEGG Gene (Rattus norvegicus):287122 Rpl3l

Monarch:287122 Rpl3l

NCBI Gene:287122 Rpl3l

UCSC:D4A9G1 Rpl3l

Reference Transcript

RefSeq:NM_001191589.1 Rpl3l

Other Identifiers

10732197

1376884_a_at

17644351

287122

5717721

5749161

5823137

5918369

6072635

6088193

6315008

6335673

6419290

6540176

6633217

A_43_P15062

A_64_P011099

GE1145063

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0010832

GO:0016202

GO:0022625

GO:0030154

GO:0043226

GO:0048856

PH_rn_0015247

rc_AA818845_at

rc_AA891037_at

rc_AA891037_g_at

Participates

as a candidate of

RPL3,RPL3L [cytosol] (Rattus norvegicus)

Inferred From

RPL3L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001178518.1

Ensembl

ENSRNOP00000019660, ENSRNOG00000014641, ENSRNOT00000019660

RGD

1306315

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