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Table of Contents
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Gnb4 [cytosol]
Stable Identifier
R-RNO-6814417
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
GNB4, O35353
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Signal amplification (Rattus norvegicus)
ADP signalling through P2Y purinoceptor 12 (Rattus norvegicus)
Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)
ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Thromboxane signalling through TP receptor (Rattus norvegicus)
G13 activation by TP receptor (Rattus norvegicus)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Gq activation by TP receptor (Rattus norvegicus)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Thrombin signalling through proteinase activated receptors (PARs) (Rattus norvegicus)
Gq activation by PAR (Rattus norvegicus)
Thrombin-activated PAR:Gq (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Thrombin-activated PAR:Gq (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Protein folding (Rattus norvegicus)
Chaperonin-mediated protein folding (Rattus norvegicus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Rattus norvegicus)
ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
PDCL binds G-protein beta and TRiC/CCT (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)
p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit [cytosol] (Rattus norvegicus)
G-protein beta 1-4 subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta 1-4 subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Neuronal System (Rattus norvegicus)
Potassium Channels (Rattus norvegicus)
Inwardly rectifying K+ channels (Rattus norvegicus)
G protein gated Potassium channels (Rattus norvegicus)
Activation of G protein gated Potassium channels (Rattus norvegicus)
Activation of GIRK/Kir3 Channels (Rattus norvegicus)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
GABA receptor activation (Rattus norvegicus)
GABA B receptor activation (Rattus norvegicus)
Activation of GABAB receptors (Rattus norvegicus)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Rattus norvegicus)
Activation of GIRK/Kir3 Channels (Rattus norvegicus)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein activation (Rattus norvegicus)
The receptor:G-protein complex binds GTP (Rattus norvegicus)
Opioid:MOR:G protein-GTP complex [plasma membrane] (Rattus norvegicus)
G protein-GTP [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
The receptor:G-protein complex releases GDP (Rattus norvegicus)
Opioid:MOR:G protein-GDP complex [plasma membrane] (Rattus norvegicus)
G protein-GDP complex [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Opsins act as GEFs for G alpha-t (Rattus norvegicus)
G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Rattus norvegicus)
G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Rattus norvegicus)
G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G alpha (z) signalling events (Rattus norvegicus)
Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gz (active) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through CDC42 (Rattus norvegicus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
G-protein beta-gamma:PI3K gamma [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class B/2 (Secretin family receptors) (Rattus norvegicus)
Glucagon-type ligand receptors (Rattus norvegicus)
Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1 (Rattus norvegicus)
GLP-1:GLP-1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
G-beta:G-gamma (candidates) [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
GLP-1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
G-beta:G-gamma (candidates) [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
Ca2+ pathway (Rattus norvegicus)
WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
G-protein beta subunit [cytosol] (Rattus norvegicus)
Gnb4 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O35353
Gene Names
Gnb4
Reference Genes
BioGPS Gene:294962 Gnb4
ENSEMBL:ENSRNOG00000011070
KEGG Gene (Rattus norvegicus):294962 Gnb4
Monarch:294962 Gnb4
NCBI Gene:294962 Gnb4
UCSC:O35353 Gnb4
Reference Transcript
RefSeq:NM_001013910.2 Gnb4
Participant Of
hasMember
G-protein beta 1-4 subunit [cytosol]
hasCandidate
G-protein beta subunit [cytosol]
G-protein beta subunit [cytosol]
Other forms of this molecule
Gnb4 [plasma membrane]
Inferred From
Partially folded GNB4 [cytosol] (Homo sapiens)
Unfolded GNB4 [cytosol] (Homo sapiens)
GNB4 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001013932.1
PRO
O35353
RGD
1359321
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