Shank1,3 binds Homer1a

Stable Identifier
R-RNO-6794343
Type
Reaction
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Shank1,3 binds Homer1a

Homer with its EVH1 domain binds to proline-rich motif of Shank family members. Shank and Homer coimmunoprecipitate from brain and colocalize at postsynaptic densities. Shank uses distinct domains to bind to GKAP and Homer, thus it can bridge between these two proteins. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors (Tu et al. 1999).

Literature References
PubMed ID Title Journal Year
11498055 Regulation of dendritic spine morphology and synaptic function by Shank and Homer

Sala, C, Piƫch, V, Wilson, NR, Passafaro, M, Liu, G, Sheng, M

Neuron 2001
10433269 Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

Tu, JC, Xiao, B, Naisbitt, S, Yuan, JP, Petralia, RS, Brakeman, P, Doan, A, Aakalu, VK, Lanahan, AA, Sheng, M, Worley, PF

Neuron 1999
Participants
Orthologous Events
Authored
Reviewed
Created