GKAP bind Psd-95

Stable Identifier
Reaction [binding]
Rattus norvegicus
SVG |   | PPTX  | SBGN
GKAP bind Psd-95

Guanylate kinase-associated protein (GKAP; also known as synapse-associated 42 protein 90-postsynaptic density-95-associated protein (SAPAP) and Discs-large-associated 43 protein (DAP) family proteins) a synaptic protein is one of the major constituent of the postsynaptic density (PSD). GKAP binds directly to the GK (guanylate kinase-like) domain of the four known members of the PSD-95 (postsynaptic density protein 95) family (Kim et al. 1997, Naisbitt et al. 1997, Takeuchi et al. 1997). GKAP is therefore one of the major scaffold proteins organizing glutamate receptors in the PSD.

Literature References
PubMed ID Title Journal Year
9221768 Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90

Sheng, M, Kim, E, Naisbitt, S, Yang, FC, Weinberg, RJ, Craig, AM, Rao, A

J. Neurosci. 1997
9115257 SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density

Hata, Y, Hirao, K, Takai, Y, Irie, M, Toyoda, A, Takeuchi, M

J. Biol. Chem. 1997
9024696 GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules

Sheng, M, Kim, E, Hsueh, YP, Rothschild, A, Naisbitt, S, Craig, AM, Rao, A

J. Cell Biol. 1997
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