Spine-Associated RapGAP (SPAR) is a postsynaptic Rap-specific GTPase-activating protein (RapGAP) that reorganizes actin cytoskeleton and drives dentritic spine head growth. SPAR interacts with the guanylate kinase-like (GK) domain of Disks large homolog proteins (DSGs) forming a complex with NMDA receptors in brain (Pak et al. 2001).
Pak, DT, Yang, S, Rudolph-Correia, S, Kim, E, Sheng, M
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