Reactome | Grin2a [plasma membrane]

Grin2a [plasma membrane]

Stable Identifier

R-RNO-6794271

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Nr2a, Glutamate receptor ionotropic, NMDA 2A, NMDE1_RAT

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Protein-protein interactions at synapses (Rattus norvegicus)
  - Synaptic adhesion-like molecules (Rattus norvegicus)
    - PSD-95 binds NMDA receptor (Rattus norvegicus)
      - NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
    - SALM1 binds NMDA receptor (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
    - SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)
      - AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Assembly and cell surface presentation of NMDA receptors (Rattus norvegicus)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
        
        Grin1:Grin2a di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)
        
        Grin1:Grin2a di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        Grin2a [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q00959 Grin2a

Gene Names

Grin2a

Chain

signal peptide:1-22, chain:23-1464

Reference Genes

BioGPS Gene:24409 Grin2a

KEGG Gene (Rattus norvegicus):24409 Grin2a

Monarch:24409 Grin2a

NCBI Gene:24409 Grin2a

UCSC:Q00959 Grin2a

Reference Transcript

RefSeq:NM_012573.3 Grin2a

Participates

as a component of

as a member of

NR2 subunits [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

p-Y-Grin2a [plasma membrane]

Grin2a [endoplasmic reticulum membrane]

Inferred From

GRIN2A [plasma membrane] (Homo sapiens)

Cross References

ZINC - Investigational

NMDE1_RAT

RefSeq

NP_036705.3

ZINC - Substances

NMDE1_RAT

ZINC - Biogenic

NMDE1_RAT

ZINC target

Q00959

PRO

Q00959

ZINC - Predictions - Purchasable

NMDE1_RAT

RGD

2737

PDB

5TQ0, 5I56, 5TQ2, 6MMU, 5I59, 6MMX, 6MMH, 6MMG, 5I57, 5I58, 6MMW, 6MMM, 6MML, 6OVE, 4NF6, 5VIJ, 6ODL, 4NF8, 6MM9, 4NF5, 5VIH, 5VII, 6MMB, 6MMV, 6UZW, 5TPW, 6UZR, 6MMA, 6MMT, 5U8C, 4JWX, 6MMJ, 5DEX, 6MMI, 6UZX, 2A5S, 4NF4, 2A5T, 6UZ6, 6MMK, 6USU, 6USV, 6OVD, 6MMS, 5JTY, 6UZG, 6MMR, 6MMP, 6MMN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [plasma membrane] (R-RNO-9612601)	0.791	8
UniProt:P11275 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-RNO-432796) phospho-p-T286-CAMK2A [nucleoplasm] (R-RNO-444797) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-RNO-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-RNO-4332334) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.589	2
UniProt:Q8R4I7 NETO1			0.576	4
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) SRC-1 [plasma membrane] (R-MMU-65043) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) Activated Src [nucleoplasm] (R-MMU-8937700) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) p-Y416-Src [cytosol] (R-MMU-8964306) phospho-p-Y416-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701)	0.558	4