Reactome | Ap2a2 [endolysosome membrane]

Ap2a2 [endolysosome membrane]

Stable Identifier

R-RNO-6784819

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

endolysosome membrane

Synonyms

AP2A2(1-939), P18484

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - MHC class II antigen presentation (Rattus norvegicus)
    - Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)
    - Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)
      - Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)

Transport of small molecules (Rattus norvegicus)

- Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
  - Plasma lipoprotein clearance (Rattus norvegicus)
    - LDL clearance (Rattus norvegicus)
      - Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)
      - PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)
    - VLDLR internalisation and degradation (Rattus norvegicus)
      - VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)
        
        VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Rattus norvegicus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)
        
        Ap2a2 [endolysosome membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P18484 Ap2a2

Gene Names

Ap2a2, Adtab

Chain

initiator methionine:1, chain:2-938

Reference Genes

UCSC:P18484 Ap2a2

Participates

as a member of

Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Rattus norvegicus)

Other forms of this molecule

Ap2a2 [secretory granule membrane]

Ap2a2 [ficolin-1-rich granule membrane]

Ap2a2 [endocytic vesicle membrane]

Ap2a2 [clathrin-coated endocytic vesicle membrane]

Ap2a2 [cytosol]

Adaptor Protein 2 alpha 2 subunit [plasma membrane]

Ap2a2 [plasma membrane]

Inferred From

AP2A2(1-939) [endolysosome membrane] (Homo sapiens)

Cross References

PRO

P18484

RGD

71015

PDB

4NEE, 2VGL, 6YAH, 2XA7, 6QH5, 4UQI, 6QH7, 6OWT, 6YAF, 6QH6

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88339	2	Epn1 [plasma membrane] (R-RNO-182952) Epn1 [cytosol] (R-RNO-8865826)	0.775	6
UniProt:P21707	6	Syt1 [plasma membrane] (R-RNO-168786) Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-RNO-917741) Syt1 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-372508) Syt1 [clathrin-sculpted glutamate transport vesicle membrane] (R-RNO-372514) Syt1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-RNO-210536) Syt1 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869113)	0.589	5