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ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
Stable Identifier
R-RNO-6781841
Type
Complex
Species
Rattus norvegicus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Dual incision in TC-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CUL4 [nucleoplasm]
(Rattus norvegicus)
Ddb1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of ERCC8 [nucleoplasm]
(Rattus norvegicus)
Rbx1 [nucleoplasm]
(Rattus norvegicus)
Participates
as a component of
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Rattus norvegicus)
Inferred From
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
(Homo sapiens)
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