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Xpa [nucleoplasm]
Stable Identifier
R-RNO-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
XPA, A0A8I6G6T5
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
Dual Incision in GG-NER (Rattus norvegicus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Rattus norvegicus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Formation of Incision Complex in GG-NER (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Rattus norvegicus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
CHD1L is recruited to GG-NER site (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Formation of the pre-incision complex in GG-NER (Rattus norvegicus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Recruitment of XPA and release of CAK (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
SUMOylation of XPC (Rattus norvegicus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Dual incision in TC-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
Xpa [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G6T5
Gene Names
Xpa
Reference Genes
ENSEMBL:ENSRNOG00000009576
ENSEMBL:ENSRNOG00000009576.6 Xpa
Reference Transcript
RefSeq:XM_006238036.3 Xpa
Other Identifiers
10876567
1384029_at
17807058
298074
5750626
5949223
6194421
6315621
6318869
6487228
6698211
A_44_P1018246
GO:0000228
GO:0003677
GO:0003684
GO:0005634
GO:0005654
GO:0005662
GO:0005694
GO:0006281
GO:0006289
GO:0009650
GO:0019904
GO:0034504
GO:0042803
GO:0043226
GO:0045171
GO:1990837
ILMN_1355648
Participates
as an output of
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
as an input of
Recruitment of XPA and release of CAK (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
as a component of
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006238098.1
Ensembl
ENSRNOT00000108242
,
ENSRNOP00000080582
,
ENSRNOG00000009576
RGD
1308769
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