Reactome | Tradd [cytosol]

Tradd [cytosol]

Stable Identifier

R-RNO-66376

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

TRADD, D3ZZC5

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Rattus norvegicus)

- Apoptosis (Rattus norvegicus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
    - Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
      - Dimerization of procaspase-8 (Rattus norvegicus)
        
        TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
      - Regulation by c-FLIP (Rattus norvegicus)
        
        Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
        
        TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
- Regulated Necrosis (Rattus norvegicus)
  - RIPK1-mediated regulated necrosis (Rattus norvegicus)
    - Regulation of necroptotic cell death (Rattus norvegicus)
      - CASP8 activity is inhibited (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
      - RIPK1 is cleaved by CASP8 (Rattus norvegicus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)
        
        TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Rattus norvegicus)
        
        Tradd [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZZC5

Gene Names

Tradd

Reference Genes

BioGPS Gene:246756 Tradd

ENSEMBL:ENSRNOG00000015179

ENSEMBL:ENSRNOG00000015179.7 Tradd

KEGG Gene (Rattus norvegicus):246756 Tradd

Monarch:246756 Tradd

NCBI Gene:246756 Tradd

Reference Transcript

Other Identifiers

10810556

1390434_at

17733008

246756

5696305

5758154

5809491

5875982

5917143

5963617

6027022

6272693

6389914

A_42_P509843

A_44_P527610

A_44_P527611

A_64_P000604

GE1281192

GO:0002947

GO:0005068

GO:0005515

GO:0005737

GO:0005886

GO:0006954

GO:0007165

GO:0007249

GO:0012501

GO:0019900

GO:0023052

GO:0030335

GO:0033209

GO:0035591

GO:0042802

GO:0043123

GO:0043235

GO:0048856

GO:0048870

GO:0050729

GO:0051798

GO:0060090

GO:0070513

GO:0071356

GO:0097191

ILMN_1372817

PH_rn_0014500

PH_rn_0020649

rc_AI180206_at

Participates

as an input of

as a component of

Inferred From

TRADD [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006255506.1, NP_001093950.1

Ensembl

ENSRNOG00000015179, ENSRNOT00000020405, ENSRNOP00000020405

RGD

621313

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