Reactome | Gtf2h2 [nucleoplasm]

Gtf2h2 [nucleoplasm]

Stable Identifier

R-RNO-65914

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

GTF2H2, A0JN27

Locations in the PathwayBrowser

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DNA Repair (Rattus norvegicus)

- Nucleotide Excision Repair (Rattus norvegicus)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
    - Dual Incision in GG-NER (Rattus norvegicus)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Rattus norvegicus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
    - Formation of Incision Complex in GG-NER (Rattus norvegicus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Rattus norvegicus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - CHD1L is recruited to GG-NER site (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - Formation of the pre-incision complex in GG-NER (Rattus norvegicus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Rattus norvegicus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - Recruitment of XPA and release of CAK (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - SUMOylation of XPC (Rattus norvegicus)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Rattus norvegicus)
        
        TFIIH Core [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
    - Dual incision in TC-NER (Rattus norvegicus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
        
        TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
    - Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC6 binds stalled RNA Pol II (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
        
        TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        TFIIH [nucleoplasm] (Rattus norvegicus)
        
        Gtf2h2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0JN27

Gene Names

Gtf2h2

Reference Genes

BioGPS Gene:294693 Gtf2h2

ENSEMBL:ENSRNOG00000018230

ENSEMBL:ENSRNOG00000018230.8 Gtf2h2

ENSEMBL:ENSRNOG00055027191

ENSEMBL:ENSRNOG00060026612

ENSEMBL:ENSRNOG00065022496

KEGG Gene (Rattus norvegicus):294693 Gtf2h2

Monarch:294693 Gtf2h2

NCBI Gene:294693 Gtf2h2

UCSC:A0JN27 Gtf2h2

Reference Transcript

Other Identifiers

10820934

1385803_at

17744799

294693

5630163

5670579

5797741

5801152

5849625

5858398

5858470

6001949

6098351

6193673

6243931

6271169

6362888

6374775

6453929

6529314

6607218

6617721

6717373

A_44_P1033819

GE12949

GO:0000439

GO:0005634

GO:0006281

GO:0006289

GO:0006351

GO:0008270

GO:0043226

ILMN_1350152

PH_rn_0007379

rc_AA957770_at

Participates

as a component of

Inferred From

GTF2H2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006231906.1, NP_001070896.1, XP_006231907.1

Ensembl

ENSRNOT00000061183, ENSRNOG00000018230, ENSRNOP00000057895

PRO

A0JN27

RGD

1310499

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