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MAPK3 [cytosol]
Stable Identifier
R-RNO-59284
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P21708
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
L1CAM interactions (Rattus norvegicus)
Signal transduction by L1 (Rattus norvegicus)
MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)
p-2S-MAP2K1:MAPK3 [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Thrombin signalling through proteinase activated receptors (PARs) (Rattus norvegicus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Rattus norvegicus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Growth hormone receptor signaling (Rattus norvegicus)
Lyn activates ERK (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
ISG15 antiviral mechanism (Rattus norvegicus)
ISGylation of host proteins (Rattus norvegicus)
ISG15 targets [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
ISGylated host proteins [cytosol] (Rattus norvegicus)
ISG15 targets [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)
ISG15 targets [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
ISGylated host proteins [cytosol] (Rattus norvegicus)
ISG15 targets [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
IFNG signaling activates MAPKs (Rattus norvegicus)
JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
MAPK monomers and dimers [cytosol] (Rattus norvegicus)
MAPK3 dimer [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPK3 (ERK1) activation (Rattus norvegicus)
MAP2K1 binds MAPK3 (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
p-2S-MAP2K1:MAPK3 [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)
p-2S-MAP2K1:MAPK3 [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
MAPK monomers and dimers [cytosol] (Rattus norvegicus)
MAPK3 dimer [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
Signal attenuation (Rattus norvegicus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)
MAPK3,(MAPK1) [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)
MAPK3,(MAPK1) [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
MAPK3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P21708 Mapk3
Gene Names
Mapk3, Erk1, Prkm3
Chain
initiator methionine:, chain:2-380
Reference Genes
BioGPS Gene:50689 Mapk3
ENSEMBL:ENSRNOG00055026224 Mapk3
ENSEMBL:ENSRNOG00060030957 Mapk3
ENSEMBL:ENSRNOG00065016730 Mapk3
KEGG Gene (Rattus norvegicus):50689 Mapk3
Monarch:50689 Mapk3
NCBI Gene:50689 Mapk3
UCSC:P21708 Mapk3
Reference Transcript
RefSeq:NM_017347.2 Mapk3
Participates
as a member of
ISG15 targets [cytosol] (Rattus norvegicus)
MAPK3,(MAPK1) [cytosol] (Rattus norvegicus)
MAPKs [cytosol] (Rattus norvegicus)
as a component of
MAPK3 dimer [cytosol] (Rattus norvegicus)
p-2S-MAP2K1:MAPK3 [cytosol] (Rattus norvegicus)
as an input of
MAP2K1 binds MAPK3 (Rattus norvegicus)
Other forms of this molecule
Mapk3 [cytosol]
phospho-p-Y204-MAPK3-3 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
MAPK3 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
Inferred From
MAPK3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_059043.1
IntEnz
2.7.11.24
PRO
P21708
RGD
3046
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