Reactome | 'activator' RAFs [cytosol]

'activator' RAFs [cytosol]

Stable Identifier

R-RNO-5672709

Type

Set [CandidateSet]

Species

Rattus norvegicus

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        Dissociation of RAS:RAF complex (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        RAF phosphorylates MAP2K dimer (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
      - Negative regulation of MAPK pathway (Rattus norvegicus)
        
        PEBP1 binds activated RAF1 (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        PP2A dephosphorylates RAF1 (Rattus norvegicus)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
      - RAF activation (Rattus norvegicus)
        
        "Activator" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Phosphorylation of RAF (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        'activator' RAF:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        'activator' RAFs [cytosol] (Rattus norvegicus)

Participants

members

phospho-Braf [cytosol] (Rattus norvegicus)

candidates

Participates

as a component of

Inferred From

'activator' RAFs [cytosol] (Homo sapiens)

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