Reactome | LAMTOR1 [lysosomal membrane]

LAMTOR1 [lysosomal membrane]

Stable Identifier

R-RNO-5653582

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

lysosomal membrane

Synonyms

Q6P791

Locations in the PathwayBrowser

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Autophagy (Rattus norvegicus)

- Macroautophagy (Rattus norvegicus)
  - Active mTORC1 binds the ULK1 complex (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Active mTORC1 phosphorylates ULK1 (Rattus norvegicus)
    - mTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Rheb in the mTORC1 complex hydrolyses GTP (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - mTORC1 dissociates from ULK complex (Rattus norvegicus)
    - mTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
    - mTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Amino acids regulate mTORC1 (Rattus norvegicus)
    - RRAGA,B exchanges GDP for GTP (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - RRAGA,B hydrolyzes GTP (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
      - Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - RRAGC,D hydrolyzes GTP (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1 binds RHEB:GTP (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Metabolic Genes (Rattus norvegicus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        MAF1 translocates to the nucleus (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 phosphorylates MAF1 (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
- mTOR signalling (Rattus norvegicus)
  - AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Formation of Ragulator complex (Rattus norvegicus)
    - LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - Ragulator [lysosomal membrane] (Rattus norvegicus)
      - LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Formation of active mTORC1 complex (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Ragulator binds Rag dimers (Rattus norvegicus)
    - Ragulator [lysosomal membrane] (Rattus norvegicus)
      - LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
      - Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
      - Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
  - mTORC1-mediated signalling (Rattus norvegicus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        LAMTOR1 [lysosomal membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6P791

Reference Genes

BioGPS Gene:100361543

BioGPS Gene:308869

ENSEMBL:ENSRNOG00000020016

KEGG Gene (Rattus norvegicus):100361543

KEGG Gene (Rattus norvegicus):308869

Monarch:100361543

Monarch:308869

NCBI Gene:100361543

NCBI Gene:308869

UCSC:Q6P791

Reference Transcript

Other Identifiers

100361543

10709268

10933587

1388980_at

17618929

2319924

308869

5772865

5889256

6021460

6058173

6070755

6160498

6338112

6527471

6653314

6717389

735078

A_44_P410272

A_64_P005008

AAH61783

BC061783

ENSRNOG00000020016

ENSRNOP00000027150

ENSRNOT00000027150

EntrezGene:100361543

EntrezGene:308869

EntrezGene:Lamtor1

EntrezGene:LOC100361543

GE18942

GO:0001558

GO:0001919

GO:0003674

GO:0005085

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0006464

GO:0006629

GO:0006810

GO:0007032

GO:0007040

GO:0007165

GO:0008150

GO:0010872

GO:0010874

GO:0016020

GO:0016192

GO:0016197

GO:0019899

GO:0031410

GO:0031902

GO:0032008

GO:0032418

GO:0032991

GO:0034613

GO:0040007

GO:0042592

GO:0042632

GO:0043226

GO:0043410

GO:0045121

GO:0051020

GO:0060090

GO:0060620

GO:0071230

GO:0071986

ILMN_1352579

IPR028209

Lamtor1

LOC100361543

LOC100361543-201

NM_199102

NP_954533

PF15454

PH_rn_0022903

PH_rn_0024348

rc_AA799718_at

SM01262

UPI0000181D61

XM_002727567

XM_002730236

XP_002727613

XP_002730282

Participant Of

input

Formation of Ragulator complex

hasComponent

Ragulator [lysosomal membrane]

Other forms of this molecule

LAMTOR1 [ficolin-1-rich granule membrane]

LAMTOR1 [azurophil granule membrane]

LAMTOR1 [plasma membrane]

LAMTOR1 [specific granule membrane]

Inferred From

LAMTOR1 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

NP_954533.1, XP_002730282.1, XP_002727613.1

PRO

Q6P791

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88653	5	LAMTOR3 [plasma membrane] (R-MMU-6806307) LAMTOR3 [tertiary granule membrane] (R-MMU-6800189) LAMTOR3 [specific granule membrane] (R-MMU-6800178) LAMTOR3 [endosome membrane] (R-MMU-5693294) LAMTOR3 [lysosomal membrane] (R-MMU-5653581)	0.644	5
UniProt:Q9JHS3	5	LAMTOR2 [plasma membrane] (R-MMU-6806286) LAMTOR2 [tertiary granule membrane] (R-MMU-6800165) LAMTOR2 [specific granule membrane] (R-MMU-6800168) LAMTOR2 [endosome membrane] (R-MMU-5693293) LAMTOR2 [lysosomal membrane] (R-MMU-5653583)	0.61	4