Reactome | CAMKK2 [nucleoplasm]

CAMKK2 [nucleoplasm]

Stable Identifier

R-RNO-5336483

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

O88831

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Post NMDA receptor activation events (Rattus norvegicus)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Rattus norvegicus)
        
        CaMKK autophosphorylates in the nucleus (Rattus norvegicus)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Rattus norvegicus)
        
        CaMKK [nucleoplasm] (Rattus norvegicus)
        
        CAMKK2 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - DAG and IP3 signaling (Rattus norvegicus)
    - CaM pathway (Rattus norvegicus)
      - Calmodulin induced events (Rattus norvegicus)
        
        CaMK IV-mediated phosphorylation of CREB (Rattus norvegicus)
        
        CaMKK autophosphorylates in the nucleus (Rattus norvegicus)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Rattus norvegicus)
        
        CaMKK [nucleoplasm] (Rattus norvegicus)
        
        CAMKK2 [nucleoplasm] (Rattus norvegicus)
- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Opioid Signalling (Rattus norvegicus)
        
        G-protein mediated events (Rattus norvegicus)
        
        PLC beta mediated events (Rattus norvegicus)
        
        Ca-dependent events (Rattus norvegicus)
        
        CaM pathway (Rattus norvegicus)
        
        Calmodulin induced events (Rattus norvegicus)
        
        CaMK IV-mediated phosphorylation of CREB (Rattus norvegicus)
        
        CaMKK autophosphorylates in the nucleus (Rattus norvegicus)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Rattus norvegicus)
        
        CaMKK [nucleoplasm] (Rattus norvegicus)
        
        CAMKK2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O88831 Camkk2

Gene Names

Camkk2

Chain

initiator methionine:, chain:2-587

Reference Genes

BioGPS Gene:83506 Camkk2

KEGG Gene (Rattus norvegicus):83506 Camkk2

Monarch:83506 Camkk2

NCBI Gene:83506 Camkk2

UCSC:O88831 Camkk2

Reference Transcript

RefSeq:NM_031338.1 Camkk2

Participates

as a member of

CaMKK [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

phospho-p-CAMKK2 [cytosol]

CAMKK2 [cytosol]

p-Camkk2 [nucleoplasm]

phospho-p-CAMKK2 [nucleoplasm]

Inferred From

CAMKK2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_112628.1

PRO

O88831

RGD

620092

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