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phospho-Mlkl [cytosol]
Stable Identifier
R-RNO-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
p-T357,S358-MLKL, A0A8I5ZV82
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
MLKL binds PIPs (Rattus norvegicus)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
RIPK3 phosphorylates MLKL (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
ITCH polyubiquitinates MLKL at K50 (Rattus norvegicus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
MLKL binds FLOT1, FLOT2 (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
MLKL binds IP4, IP5 and IP6 (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
MLKL binds ITCH (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Rattus norvegicus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Stimuli-sensing channels (Rattus norvegicus)
TRP channels (Rattus norvegicus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
phospho-Mlkl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I5ZV82
Gene Names
Mlkl
Reference Genes
BioGPS Gene:690743 Mlkl
ENSEMBL:ENSRNOG00000042353
ENSEMBL:ENSRNOG00000042353.5 Mlkl
KEGG Gene (Rattus norvegicus):690743 Mlkl
Monarch:690743 Mlkl
NCBI Gene:690743 Mlkl
Reference Transcript
RefSeq:XM_008772570.2 Mlkl
RefSeq:XM_003753111.3 Mlkl
RefSeq:XM_008772571.2 Mlkl
RefSeq:XM_008774238.1 Mlkl
RefSeq:XM_006222737.2 Mlkl
RefSeq:XM_006222738.2 Mlkl
RefSeq:XM_008772572.2 Mlkl
RefSeq:XM_008774237.1 Mlkl
Other Identifiers
17733638
5761770
5782018
5893919
6185061
6360339
6428113
6484152
6575101
6659401
6676306
690743
A_44_P520603
GO:0003824
GO:0004672
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007166
GO:0012501
GO:0016740
GO:0019901
GO:0023052
GO:0030054
GO:0036211
GO:0043226
GO:0044877
GO:0051607
GO:0065003
GO:0070207
GO:0070266
GO:0097527
GO:0097528
GO:0098542
GO:0140096
PH_rn_0020326
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Mlkl [cytosol]
Mlkl [cytosol]
Inferred From
p-T357,S358-MLKL [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 358 (in Homo sapiens)
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357 (in Homo sapiens)
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_006222800.1
,
XP_008770794.1
,
XP_008770792.1
,
XP_008770793.1
,
XP_008772460.1
,
XP_006222799.1
,
XP_008772459.1
,
XP_003753159.1
Ensembl
ENSRNOT00000095360
,
ENSRNOG00000042353
,
ENSRNOP00000081539
RGD
1592221
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