Reactome | SLC38A9 [lysosomal membrane]

SLC38A9 [lysosomal membrane]

Stable Identifier

R-RNO-5215938

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

lysosomal membrane

Synonyms

Q3B8Q3

Locations in the PathwayBrowser

Expand all

Autophagy (Rattus norvegicus)

- Macroautophagy (Rattus norvegicus)
  - Active MTORC1 binds the ULK1 complex (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - MTORC1 dissociates from ULK complex (Rattus norvegicus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Metabolic Genes (Rattus norvegicus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        MAF1 translocates to the nucleus (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 phosphorylates MAF1 (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
- MTOR signalling (Rattus norvegicus)
  - AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Formation of active mTORC1 complex (Rattus norvegicus)
    - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
  - mTORC1-mediated signalling (Rattus norvegicus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
      - Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
        
        Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
        
        SLC38A9 [lysosomal membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q3B8Q3

Reference Genes

BioGPS Gene:310091

ENSEMBL:ENSRNOG00000009851

ENSEMBL:ENSRNOG00000009851.7

ENSEMBL:ENSRNOG00055011365

ENSEMBL:ENSRNOG00060004297

ENSEMBL:ENSRNOG00065020359

KEGG Gene (Rattus norvegicus):310091

Monarch:310091

NCBI Gene:310091

Reference Transcript

Other Identifiers

10813029

17735776

310091

5618385

5618628

5667073

5872182

5922942

5926578

5983594

6023468

6048261

6072665

6189122

6221941

6225040

6338582

6396159

6475271

6645875

A_44_P316440

GO:0003333

GO:0005085

GO:0005215

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0006867

GO:0006868

GO:0008289

GO:0015171

GO:0015182

GO:0015186

GO:0015190

GO:0015485

GO:0023052

GO:0031410

GO:0032008

GO:0032935

GO:0043226

GO:0055085

GO:0061459

GO:0071230

GO:0071986

GO:0098772

GO:0140299

GO:1903826

GO:1904263

GO:1990877

PH_rn_0004719

Participates

as a component of

as an input of

SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)

Inferred From

SLC38A9 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

XP_006231995.1, XP_006231991.1, XP_006231993.1, XP_006231992.1, NP_001030328.1, XP_006231994.1

Ensembl

ENSRNOP00000013218, ENSRNOT00000013218, ENSRNOG00000009851

PRO

Q3B8Q3

RGD

1311881

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