Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
WNT5A:FZD4:p-DVL2 [plasma membrane]
Stable Identifier
R-RNO-5138442
Type
Complex
Species
Rattus norvegicus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
PCP/CE pathway (Rattus norvegicus)
WNT5A-dependent internalization of FZD4 (Rattus norvegicus)
DVL2 is phosphorylated by PKC (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
BAR domain proteins recruit dynamin (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
ARRB bind GPCRs (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Clathrin recruits PIK3C2A (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Rattus norvegicus)
p-Dvl2 [cytosol]
(Rattus norvegicus)
Participates
as a member of
ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
as an input of
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)
as an output of
DVL2 is phosphorylated by PKC (Rattus norvegicus)
Inferred From
WNT5A:FZD4:p-DVL2 [plasma membrane]
(Homo sapiens)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
