Reactome | phospho-p-Y-JAK1 [cytosol]

phospho-p-Y-JAK1 [cytosol]

Stable Identifier

R-RNO-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

A0A8I6AM23

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Interferon Signaling (Rattus norvegicus)
    - Interferon alpha/beta signaling (Rattus norvegicus)
      - Activation of JAK kinases (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Formation of p-STAT1 homodimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of STAT2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Regulation of IFNA/IFNB signaling (Rattus norvegicus)
        
        Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
    - Interferon gamma signaling (Rattus norvegicus)
      - Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - IFNG signaling activates MAPKs (Rattus norvegicus)
        
        Activated JAK1 binds RAF1 (Rattus norvegicus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        IFNGR complex with p-JAK [plasma membrane] (Rattus norvegicus)
        
        IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - JAK2-activated MAPKs phosphorylate YBX1 (Rattus norvegicus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        IFNGR complex with p-JAK [plasma membrane] (Rattus norvegicus)
        
        IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        IFNGR complex with p-JAK [plasma membrane] (Rattus norvegicus)
        
        IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of STAT1 at Ser727 (Rattus norvegicus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Release of STAT1 dimer from active receptor unit (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Rattus norvegicus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Transphosphorylation of JAK1 (Rattus norvegicus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Rattus norvegicus)
        
        IFNGR complex with p-JAK [plasma membrane] (Rattus norvegicus)
        
        IFNGR1:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
  - Signaling by CSF3 (G-CSF) (Rattus norvegicus)
    - Inactivation of CSF3 (G-CSF) signaling (Rattus norvegicus)
      - CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Rattus norvegicus)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-10 signaling (Rattus norvegicus)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Interleukin-15 signaling (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Interleukin-2 signaling (Rattus norvegicus)
        
        JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated STAT5 is released (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Recruited STAT5 is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SHC kinases in IL2 signaling [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SYK binds IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SYK is a substrate for JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Within the IL-2R complex JAK3 phosphorylates JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2RB:p-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - Interleukin-21 signaling (Rattus norvegicus)
        
        IL21 receptor JAK phosphorylation (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL21 receptor STAT binding (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL21 receptor STAT phosphorylation (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
    - Interleukin-4 and Interleukin-13 signaling (Rattus norvegicus)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y-JAK1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6AM23

Reference Genes

ENSEMBL:ENSRNOG00000011157

ENSEMBL:ENSRNOG00000011157.7

Other Identifiers

10878286

1383478_at

1384060_at

17808864

5793815

5863528

5879603

5898569

5909429

5920899

5928026

5940098

6020031

6038289

6061002

6115563

6131140

6145713

6193188

6194560

6253983

6271965

6273918

6334821

6340778

6365625

6374757

6470691

6475305

6491838

6542669

6596311

6650320

6726718

84598

AJ000556cds_at

A_64_P124417

GE21505

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005524

GO:0005856

GO:0006468

GO:0016020

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0043226

GO:0140096

ILMN_1354897

PH_rn_0010424

rc_AA924000_at

Participates

as a component of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-Y1034,Y1035-JAK1 [cytosol]

JAK1 [endosome]

phospho-p-JAK1 [cytosol]

phospho-p-Y1034-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Ensembl

ENSRNOP00000089963, ENSRNOG00000011157, ENSRNOT00000102260

RGD

69056

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