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Il12a [extracellular region]
Stable Identifier
R-RNO-447212
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
IL12A, Q9R103
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-12 family signaling (Rattus norvegicus)
Interleukin-12 signaling (Rattus norvegicus)
IL12 bound to IL12R internalises (Rattus norvegicus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12A:IL12B translocates from late endosome lumen to extracellular region (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
Interleukin-12 binds Interleukin-12 receptor (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
Interleukin-12 dissociates from Interleukin-12 receptor (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
Interleukin-35 Signalling (Rattus norvegicus)
IL35 binds IL-12RB2:IL6ST receptor (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35 binds IL12RB2:IL12RB2 receptor (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35 binds IL6ST:IL6ST receptor (Rattus norvegicus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
Interleukin-35 translocates from the ER lumen to the extracellular region (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Rattus norvegicus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Il12a [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9R103
Gene Names
Il12a
Reference Genes
BioGPS Gene:84405 Il12a
ENSEMBL:ENSRNOG00000009468
KEGG Gene (Rattus norvegicus):84405 Il12a
Monarch:84405 Il12a
NCBI Gene:84405 Il12a
UCSC:Q9R103 Il12a
Reference Transcript
RefSeq:NM_053390.1 Il12a
Participates
as a component of
IL35 [extracellular region] (Rattus norvegicus)
IL12A:IL12B [extracellular region] (Rattus norvegicus)
Other forms of this molecule
Il12a [endoplasmic reticulum lumen]
Il12a [late endosome lumen]
Inferred From
IL12A [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_445842.1
PRO
Q9R103
RGD
620562
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