Reactome | Il2 [extracellular region]

Il2 [extracellular region]

Stable Identifier

R-RNO-447099

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

IL2, P17108

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
      - Interleukin-2 signaling (Rattus norvegicus)
        
        Interleukin-2 receptor alpha binds interleukin-2 (Rattus norvegicus)
        
        IL2:IL2RA [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Rattus norvegicus)
        
        IL2:IL2RA [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2RA [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated STAT5 is released (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Recruited STAT5 is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        SYK binds IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        SYK is a substrate for JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Within the IL-2R complex JAK3 phosphorylates JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2RA [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Il2 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P17108

Gene Names

Il2

Reference Genes

BioGPS Gene:116562 Il2

ENSEMBL:ENSRNOG00000017348

ENSEMBL:ENSRNOG00000017348.3 Il2

ENSEMBL:ENSRNOG00055002201

ENSEMBL:ENSRNOG00060008511

ENSEMBL:ENSRNOG00065008697

KEGG Gene (Rattus norvegicus):116562 Il2

Monarch:116562 Il2

NCBI Gene:116562 Il2

UCSC:P17108 Il2

Reference Transcript

RefSeq:NM_053836.1 Il2

Other Identifiers

10822909

116562

1369596_at

17747002

5674282

5905794

6017714

6105073

6259671

6521636

A_43_P12952

GE21772

GO:0002366

GO:0002376

GO:0002639

GO:0002903

GO:0005125

GO:0005134

GO:0005576

GO:0005615

GO:0006955

GO:0007155

GO:0008083

GO:0012501

GO:0023052

GO:0030154

GO:0030890

GO:0032740

GO:0036211

GO:0038110

GO:0042104

GO:0042531

GO:0048018

GO:0048856

GO:0098772

GO:1900100

ILMN_1358692

M22899_at

PH_rn_0010711

Participates

as an input of

Interleukin-2 receptor alpha binds interleukin-2 (Rattus norvegicus)

as a component of

Inferred From

IL2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_446288.1

Ensembl

ENSRNOT00000023327, ENSRNOP00000023327, ENSRNOG00000017348

PRO

P17108

RGD

620047

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