Reactome | phospho-p-IRAK2 [cytosol]

phospho-p-IRAK2 [cytosol]

Stable Identifier

R-RNO-446636

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q4QQS0

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-1 family signaling (Rattus norvegicus)
      - Interleukin-1 signaling (Rattus norvegicus)
        
        IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
        
        Activated TAK complexes [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Rattus norvegicus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)
        
        phospho-p-IRAK2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q4QQS0 Irak2

Gene Names

Irak2

Chain

chain:1-624

Reference Genes

BioGPS Gene:362418 Irak2

KEGG:rno:362418 Irak2

Monarch:362418 Irak2

NCBI Gene:362418 Irak2

UCSC:Q4QQS0 Irak2

Reference Transcript

RefSeq:NM_001025422.1 Irak2

Other Identifiers

10857891

1383474_at

17786169

362418

5658732

5706932

5804510

5820949

5910766

6009989

6034957

6050104

6062101

6108818

6121862

6172685

6388590

6398840

6475778

6600609

A_42_P541884

A_44_P161617

GE1252485

GE14125

GO:0001959

GO:0002376

GO:0003824

GO:0004672

GO:0005515

GO:0005524

GO:0006468

GO:0007165

GO:0007249

GO:0016740

GO:0023052

GO:0031663

GO:0034142

GO:0035591

GO:0036211

GO:0042803

GO:0046982

GO:0060090

GO:0070498

GO:0070555

GO:0098542

GO:0140096

ILMN_1373683

PH_rn_0011660

rc_AI145328_at

Participates

as an output of

IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Rattus norvegicus)

Other forms of this molecule

Phospho-Irak2 [cytosol]

Irak2 [cytosol]

phospho-p-IRAK2 [endosome membrane]

IRAK2 [cytosol]

phospho-p-IRAK2 [plasma membrane]

Inferred From

p-IRAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001020593.1

ENSEMBL

ENSRNOG00000021817, ENSRNOT00000029819, ENSRNOP00000034508

PRO

Q4QQS0

RGD

1309584

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