PDK1 activates PKC zeta

Stable Identifier
R-RNO-437185
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PDK1 activates PKC zeta
3-phosphoinositide dependent protein kinase-1 (Pdpk1, also known as Pdk1 and PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of protein kinase C zeta type (Prkcz, also known as PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that Pdpk1 might activate other PKCs.
Literature References
PubMed ID Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

Lee, MH, Chen, CS, Chou, MM, Johnson, J, Toker, A, Graham, LK, Hou, W, Schaffhausen, BS, Newton, AC

Curr Biol 1998
Participants
Input
Output
Catalyst Activity

3-phosphoinositide-dependent protein kinase activity of PIP3:PDK1:AKT:PKC zeta [plasma membrane]

Physical Entity
PIP3:PDK1:AKT:PKC zeta [plasma membrane] (Rattus norvegicus)
Activity
3-phosphoinositide-dependent protein kinase activity (GO:0004676)
Orthologous Events
PDPK1 activates PRKCZ (Homo sapiens)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-09-11)
Cite Us!