Reactome | Nrtn [extracellular region]

Nrtn [extracellular region]

Stable Identifier

R-RNO-434904

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

NRTN, Q811Q5

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - RET signaling (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - RET dimerizes (Rattus norvegicus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - RET tyrosine phosphorylation (Rattus norvegicus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - SHC1 in the RET complex is phosphorylated (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - p-5Y-RET complexes bind GRB2 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Rattus norvegicus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Rattus norvegicus)
        
        GDNF,NRTN [extracellular region] (Rattus norvegicus)
        
        Nrtn [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q811Q5

Gene Names

Nrtn

Reference Genes

BioGPS Gene:84423 Nrtn

ENSEMBL:ENSRNOG00000048651

ENSEMBL:ENSRNOG00000048651.2 Nrtn

KEGG Gene (Rattus norvegicus):84423 Nrtn

Monarch:84423 Nrtn

NCBI Gene:84423 Nrtn

Reference Transcript

Other Identifiers

10930890

1374048_at

17867826

5906409

5933874

6486916

6602414

84423

A_43_P15613

GE1243351

GO:0001755

GO:0007169

GO:0008083

GO:0021675

GO:0023052

GO:0030116

GO:0030154

GO:0030971

GO:0031175

GO:0048018

GO:0048856

GO:0048870

GO:0098772

ILMN_1365985

PH_rn_0014385

Participates

as a member of

GDNF,NRTN [extracellular region] (Rattus norvegicus)

Inferred From

NRTN [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_006244409.1, NP_445851.1

Ensembl

ENSRNOG00000048651, ENSRNOT00000072592, ENSRNOP00000066997

RGD

621494

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