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Arhgef7 [cytosol]
Stable Identifier
R-RNO-430346
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
ARHGEF7, O55043
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
Ephrin signaling (Rattus norvegicus)
GIT1 binds bPIX (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
PAK binds RAC and bPIX (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
PAKs autophosphorylate (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
PAKs phosphorylate MLC (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (12/13) signalling events (Rattus norvegicus)
GEFs activate RhoA,B,C (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GEFs activate RAC1 (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOA GTPase cycle (Rattus norvegicus)
RHOA GEFs activate RHOA (Rattus norvegicus)
RHOA GEFs [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOQ GTPase cycle (Rattus norvegicus)
RHOQ binds effectors at the plasma membrane (Rattus norvegicus)
RHOQ effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Rattus norvegicus)
RHOQ effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOU GTPase cycle (Rattus norvegicus)
RHOU binds effectors at the plasma membrane (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOU:GTP:RHOU effectors [plasma membrane] (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOV GTPase cycle (Rattus norvegicus)
RHOV binds effectors at the plasma membrane (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
RHOV:GTP:RHOV effectors [plasma membrane] (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
Arhgef7 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O55043 Arhgef7
Gene Names
Arhgef7, Pak3bp, Pixb
Chain
chain:1-646
Reference Genes
BioGPS Gene:114559 Arhgef7
KEGG Gene (Rattus norvegicus):114559 Arhgef7
Monarch:114559 Arhgef7
NCBI Gene:114559 Arhgef7
UCSC:O55043 Arhgef7
Reference Transcript
RefSeq:NM_001113522.1 Arhgef7
Other Identifiers
10792913
114559
1368925_a_at
1372638_at
17713118
5719272
5721063
5746233
5795668
5820727
5864339
5877744
6010378
6144436
6218760
6309130
6309623
6328255
6368667
6392252
6405106
6421360
6432517
6480693
6545481
6562589
6574354
6585368
6639645
6657691
A_64_P006087
A_64_P312700
GE1275072
GE17327
GO:0000322
GO:0001726
GO:0002244
GO:0002376
GO:0005085
GO:0005515
GO:0005622
GO:0005737
GO:0005773
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005938
GO:0007010
GO:0007030
GO:0007264
GO:0007399
GO:0008092
GO:0012501
GO:0019901
GO:0023052
GO:0030027
GO:0030032
GO:0030154
GO:0030426
GO:0031267
GO:0032092
GO:0032991
GO:0034330
GO:0035556
GO:0042995
GO:0043005
GO:0043015
GO:0043025
GO:0043065
GO:0043226
GO:0043547
GO:0043615
GO:0048856
GO:0048870
GO:0050790
GO:0060124
GO:0065003
GO:0070161
GO:0097431
GO:0098772
GO:0098794
GO:0098974
GO:0098982
GO:0099140
GO:0110165
GO:1904424
GO:1905833
ILMN_1356216
PH_rn_0012207
rc_AA859562_at
rc_AA874918_at
rc_AA875133_at
Participates
as a candidate of
RHOA GEFs [cytosol] (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
RHOQ effectors [cytosol] (Rattus norvegicus)
CDC42 effectors [cytosol] (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
RHOJ effectors [cytosol] (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
as an input of
GIT1 binds bPIX (Rattus norvegicus)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
as a member of
GEFs [cytosol] (Rattus norvegicus)
Other forms of this molecule
p-S516-Arhgef7 [cytosol]
Arhgef7 [cytosol]
Inferred From
ARHGEF7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001106994.1
Ensembl
ENSRNOT00000017947
,
ENSRNOP00000017947
,
ENSRNOG00000012934
PRO
O55043
RGD
620624
PDB
3L4F
,
2AK5
,
2G6F
,
2P4R
,
2DF6
,
2W6B
,
3QJN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13177 PAK2
11
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.655
8
UniProt:Q13191-1 CBLB
0.558
2
UniProt:P35465
5
phospho-p-S144-PAK1 [cytosol]
(R-RNO-451339)
PAK1 [plasma membrane]
(R-RNO-3928409)
phospho-p-S144,T423-PAK1 [plasma membrane]
(R-RNO-3928472)
PAK1 [cytosol]
(R-RNO-162629)
phospho-p-S144,T423-PAK1 [cytosol]
(R-RNO-399819)
0.553
2
UniProt:P41227 NAA10
0.524
3
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