Reactome | Arhgef7 [cytosol]

Arhgef7 [cytosol]

Stable Identifier

R-RNO-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ARHGEF7, O55043

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - Ephrin signaling (Rattus norvegicus)
        
        GIT1 binds bPIX (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAK binds RAC and bPIX (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAKs autophosphorylate (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAKs phosphorylate MLC (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O55043 Arhgef7

Gene Names

Arhgef7, Pak3bp, Pixb

Chain

chain:1-646

Reference Genes

BioGPS Gene:114559 Arhgef7

KEGG Gene (Rattus norvegicus):114559 Arhgef7

Monarch:114559 Arhgef7

NCBI Gene:114559 Arhgef7

UCSC:O55043 Arhgef7

Reference Transcript

RefSeq:NM_001113522.1 Arhgef7

Other Identifiers

10792913

114559

1368925_a_at

1372638_at

17713118

5719272

5721063

5746233

5795668

5820727

5864339

5877744

6010378

6144436

6218760

6309130

6309623

6328255

6368667

6392252

6405106

6421360

6432517

6480693

6545481

6562589

6574354

6585368

6639645

6657691

A_64_P006087

A_64_P312700

GE1275072

GE17327

GO:0000322

GO:0001726

GO:0002244

GO:0002376

GO:0005085

GO:0005515

GO:0005622

GO:0005737

GO:0005773

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0007010

GO:0007030

GO:0007264

GO:0007399

GO:0008092

GO:0012501

GO:0019901

GO:0023052

GO:0030027

GO:0030032

GO:0030154

GO:0030426

GO:0031267

GO:0032092

GO:0032991

GO:0034330

GO:0035556

GO:0042995

GO:0043005

GO:0043015

GO:0043025

GO:0043065

GO:0043226

GO:0043547

GO:0043615

GO:0048856

GO:0048870

GO:0050790

GO:0060124

GO:0065003

GO:0070161

GO:0097431

GO:0098772

GO:0098794

GO:0098974

GO:0098982

GO:0099140

GO:0110165

GO:1904424

GO:1905833

ILMN_1356216

PH_rn_0012207

rc_AA859562_at

rc_AA874918_at

rc_AA875133_at

Participates

as a candidate of

as an input of

GIT1 binds bPIX (Rattus norvegicus)

as a component of

as a member of

GEFs [cytosol] (Rattus norvegicus)

Other forms of this molecule

p-S516-Arhgef7 [cytosol]

Arhgef7 [cytosol]

Inferred From

ARHGEF7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001106994.1

Ensembl

ENSRNOT00000017947, ENSRNOP00000017947, ENSRNOG00000012934

PRO

O55043

RGD

620624

PDB

3L4F, 2AK5, 2G6F, 2P4R, 2DF6, 2W6B, 3QJN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.655	8
UniProt:Q13191-1 CBLB			0.558	2
UniProt:P35465	5	phospho-p-S144-PAK1 [cytosol] (R-RNO-451339) PAK1 [plasma membrane] (R-RNO-3928409) phospho-p-S144,T423-PAK1 [plasma membrane] (R-RNO-3928472) PAK1 [cytosol] (R-RNO-162629) phospho-p-S144,T423-PAK1 [cytosol] (R-RNO-399819)	0.553	2
UniProt:P41227 NAA10			0.524	3

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