Reactome | ARHGEF7 [cytosol]

ARHGEF7

Stable Identifier

R-RNO-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

O55043

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Axon guidance (Rattus norvegicus)
  - EPH-Ephrin signaling (Rattus norvegicus)
    - Ephrin signaling (Rattus norvegicus)
      - GIT1 binds bPIX (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
      - PAK binds RAC and bPIX (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
      - PAKs autophosphorylate (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
      - PAKs phosphorylate MLC (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
      - bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        ARHGEF7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O55043

Reference Genes

BioGPS Gene:114559

dbSNP Gene:114559

ENSEMBL:ENSRNOG00000012934

KEGG Gene (Rattus norvegicus):rno:114559

Monarch:114559

NCBI Gene:114559

UCSC:O55043

Reference Transcript

RefSeq:NM_001113522.1

Other Identifiers

10792913

114559

1368925_a_at

1372638_at

17713118

2AK5

2DF6

2G6F

2P4R

2W6B

3L4F

3QJN

5719272

5721063

5746233

5795668

5820727

5864339

5877744

5952942

6144436

6170149

620624

6218760

6309130

6309623

6328255

6368667

6392252

6405106

6421360

6432517

6480693

6545481

6562589

6574354

6585368

6639645

6657691

A0A0G2QC21

A_64_P006087

A_64_P312700

AAC39971

AF044673

Arhgef7

Arhgef7-201

ENSRNOG00000012934

ENSRNOP00000017947

ENSRNOT00000017947

EntrezGene:114559

GE1275072

GE17327

GO:0001726

GO:0003674

GO:0005085

GO:0005089

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005925

GO:0005938

GO:0007165

GO:0007264

GO:0007399

GO:0008150

GO:0008219

GO:0019899

GO:0019901

GO:0022607

GO:0030027

GO:0030032

GO:0030054

GO:0030154

GO:0030426

GO:0032991

GO:0035023

GO:0035556

GO:0040011

GO:0042995

GO:0043065

GO:0043615

GO:0048365

GO:0048856

GO:0048870

ILMN_1356216

IPR000219

IPR001331

IPR001452

IPR001849

IPR011511

IPR011993

IPR032409

NM_001113521

NM_001113522

NM_053740

NP_001106993

NP_001106994

NP_446192

PF00169

PF00621

PF07653

PF16523

PF16614

PH_rn_0012207

PR00452

rc_AA859562_at

rc_AA874918_at

rc_AA875133_at

Rn.146763

SM00233

SM00325

SM00326

UPI0000131B53

XM_008771377

XM_008771379

XM_008771380

XP_008769599

XP_008769601

XP_008769602

Participant Of

hasMember

GEFs [cytosol]

input

GIT1 binds bPIX

hasComponent

Inferred From

ARHGEF7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001106994.1

PRO

O55043

BRENDA (Rattus norvegicus)

6.3.2, 2.7.1.37

PDB

2AK5, 2G6F, 2P4R, 3QJN, 3L4F, 2W6B, 2DF6

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	PAK2 [cytosol] (R-HSA-211604) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946)	0.655	8
UniProt:Q13191-1 CBLB			0.558	2
UniProt:P35465	5	phospho-p-S144,T423-PAK1 [plasma membrane] (R-RNO-3928472) PAK1 [plasma membrane] (R-RNO-3928409) phospho-p-S144-PAK1 [cytosol] (R-RNO-451339) PAK1 [cytosol] (R-RNO-162629) phospho-p-S144,T423-PAK1 [cytosol] (R-RNO-399819)	0.553	2
UniProt:P41227 NAA10			0.524	3