Reactome | Interaction of NCAM1 with GFRalpha-1

Interaction of NCAM1 with GFRalpha-1

Stable Identifier

R-RNO-420383

Type

Reaction [binding]

Species

Rattus norvegicus

Compartment

plasma membrane

ReviewStatus

5/5

General

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GFRalpha receptors GFRalpha1 and possibly also GFRalpha2 and GFRalpha4 subunit of the GDNF (glial cell line-derived neurotrophic factor) receptor interact in cis with NCAM and functions as a coreceptor for GDNF in the absence of RET. The NCAM1-GFRalpha1 interaction down regulates NCAM1-mediated cell adhesion and promotes GDNF-NCAM1 binding.

Literature References

PubMed ID	Title	Journal	Year
12837245	The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands Ledda, F, Ibanez, CF, Paratcha, G	Cell	2003
15748846	GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons Pozas, E, Ibáñez, CF	Neuron	2005
18597864	GDNF and GFRalpha: a versatile molecular complex for developing neurons Ledda, F, Paratcha, G	Trends Neurosci	2008

Participants

Input

Output

NCAM1:GFRalpha-1 [plasma membrane] (Rattus norvegicus)

Orthologous Events

Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)

Authored

Garapati, P V (2009-02-24)

Reviewed

Walmod, PS (2009-05-26)

Maness, PF (2009-05-26)

Created

Garapati, P V (2009-05-11)

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