Reactome | Sptbn5 [cytosol]

Sptbn5 [cytosol]

Stable Identifier

R-RNO-420047

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

SPTBN5, A0A0G2JY25

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - L1CAM interactions (Rattus norvegicus)
      - Interaction between L1 and Ankyrins (Rattus norvegicus)
        
        L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)
        
        L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB:F-actin [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB:F-actin [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
    - NCAM signaling for neurite out-growth (Rattus norvegicus)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPI-mediated anterograde transport (Rattus norvegicus)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        COPI vesicle uncoating (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Rattus norvegicus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Rattus norvegicus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPI-mediated anterograde transport (Rattus norvegicus)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - COPI vesicle uncoating (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Rattus norvegicus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Rattus norvegicus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Rattus norvegicus)
        
        Spectrin tetramer [cytosol] (Rattus norvegicus)
        
        SPTA:SPTB [cytosol] (Rattus norvegicus)
        
        Spectrin beta chain [cytosol] (Rattus norvegicus)
        
        Sptbn5 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JY25

Gene Names

Sptbn5

Reference Genes

ENSEMBL:ENSRNOG00000059260

ENSEMBL:ENSRNOG00000059260.2 Sptbn5

Other Identifiers

10848652

17775878

296090

5669315

5670578

5692836

5709500

5721653

5725244

5744248

5778104

5821101

5833304

5852503

5864707

5879850

5935265

5943160

5968332

5970690

5994056

5995487

6005010

6009692

6049038

6064360

6067395

6103151

6118546

6118620

6133617

6136743

6141388

6144310

6168318

6173530

6178632

6192851

6197168

6278079

6281199

6294643

6299208

6312213

6313802

6322350

6337504

6346197

6367816

6374831

6376327

6394501

6400014

6409523

6442675

6462279

6470074

6472366

6473241

6475426

6476392

6516589

6527410

6552806

6557616

6570880

6582610

6643074

6644579

6665768

6671783

6678835

6682432

6685902

6708381

6731035

6734997

A_44_P210868

A_64_P104232

GE1134349

GO:0002046

GO:0005515

GO:0005737

GO:0005856

GO:0005875

GO:0005929

GO:0007030

GO:0007041

GO:0008092

GO:0019894

GO:0030507

GO:0030863

GO:0032029

GO:0032391

GO:0034452

GO:0042802

GO:0043226

GO:0043621

GO:0045179

GO:0045505

GO:0051015

GO:0097381

PH_rn_0005279

PH_rn_0021132

Participates

as a member of

Spectrin beta chain [cytosol] (Rattus norvegicus)

Inferred From

SPTBN5 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOP00000070492, ENSRNOG00000059260, ENSRNOT00000077546

RGD

1311047

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