Ibsp binds collagen type I

Stable Identifier
R-RNO-4086208
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ibsp binds collagen type I
Bone sialoprotein 2 (Ibsp) is an anionic phosphorylated glycoprotein expressed almost exclusively in mineralized tissues. It is a potent nucleator of hydroxyapatite formation. The binding of IBSP to collagen is thought to be important for the initiation of bone mineralization and in the adhesion of bone cells to the mineralized matrix (Fujisawa et al. 1995, Tye et al. 2005).
Literature References
PubMed ID Title Journal Year
15703183 Identification of the type I collagen-binding domain of bone sialoprotein and characterization of the mechanism of interaction

Goldberg, HA, Tye, CE, Hunter, GK

J. Biol. Chem. 2005
Participants
Input
Output
Orthologous Events
IBSP binds collagen type I (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-07)
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