Reactome | Pik3cd [plasma membrane]

Pik3cd [plasma membrane]

Stable Identifier

R-RNO-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

PIK3CD, A0A8I5Y949

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - RET signaling (Rattus norvegicus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Regulation of T cell activation by CD28 family (Rattus norvegicus)
    - Co-stimulation by CD28 (Rattus norvegicus)
      - CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        PI3K binds CD28 (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
    - Co-stimulation by ICOS (Rattus norvegicus)
      - PI3K binds ICOS (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        ICOS:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
  - Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
        
        BCAP Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
      - CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
        
        CD19 Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
      - p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)
        
        CD19 Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
      - Regulation of signaling by CBL (Rattus norvegicus)
        
        CBL ubiquitinates PI3K (Rattus norvegicus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - Negative regulation of the PI3K/AKT network (Rattus norvegicus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
        
        PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        BCAP Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        CD19 Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        ICOS:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
    - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
      - Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        BCAP Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        CD19 Signalosome [plasma membrane] (Rattus norvegicus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)
        
        ICOS:PI3K [plasma membrane] (Rattus norvegicus)
        
        Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K delta [cytosol] (Rattus norvegicus)
        
        Pik3cd [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I5Y949

Gene Names

Pik3cd

Reference Genes

BioGPS Gene:366508 Pik3cd

ENSEMBL:ENSRNOG00000016846

Monarch:366508 Pik3cd

NCBI Gene:366508 Pik3cd

UCSC:A0A8I5Y949 Pik3cd

Reference Transcript

Other Identifiers

10881777

1373528_at

17812817

366508

5628724

5696066

5706737

5745684

5772144

5775398

5861682

5891886

5938306

5978814

5984688

6000474

6068552

6122624

6139864

6196703

6201710

6225695

6232806

6260484

6306317

6310607

6448351

6488100

6582257

6614206

6632982

6645178

6654324

6654854

6685910

A_44_P213363

GE15084

GO:0001938

GO:0005943

GO:0006629

GO:0010595

GO:0010628

GO:0016301

GO:0016303

GO:0030335

GO:0033031

GO:0038084

GO:0043491

GO:0046854

GO:1905278

ILMN_1369889

PH_rn_0011406

rc_AA893007_at

Participates

as a component of

Other forms of this molecule

Pik3cd [cytosol]

Inferred From

PIK3CD [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_063144205.1, XP_063144206.1, NP_001424205.1, NP_001424206.1

ENSEMBL

ENSRNOT00000095643, ENSRNOG00000016846, ENSRNOP00000076811

RGD

1310990

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