Reactome | Adra2b [plasma membrane]

Adra2b [plasma membrane]

Stable Identifier

R-RNO-390659

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

ADRA2B, P19328

Locations in the PathwayBrowser

Expand all

Hemostasis (Rattus norvegicus)

- Platelet activation, signaling and aggregation (Rattus norvegicus)
  - Platelet Aggregation (Plug Formation) (Rattus norvegicus)
    - Adrenaline signalling through Alpha-2 adrenergic receptor (Rattus norvegicus)
      - ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
    - G alpha (z) signalling events (Rattus norvegicus)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Amine ligand-binding receptors (Rattus norvegicus)
        
        Adrenoceptors (Rattus norvegicus)
        
        ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        α2-agonists bind ADRA2A,B,C (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)
        
        α2-agonists:ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        ADRA2A,B,C [plasma membrane] (Rattus norvegicus)
        
        Adra2b [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P19328

Gene Names

Adra2b

Reference Genes

BioGPS Gene:24174 Adra2b

ENSEMBL:ENSRNOG00000013887

ENSEMBL:ENSRNOG00000013887.7 Adra2b

ENSEMBL:ENSRNOG00055006213

ENSEMBL:ENSRNOG00060019138

ENSEMBL:ENSRNOG00065014694

KEGG Gene (Rattus norvegicus):24174 Adra2b

Monarch:24174 Adra2b

NCBI Gene:24174 Adra2b

UCSC:P19328 Adra2b

Reference Transcript

RefSeq:NM_138505.2 Adra2b

Other Identifiers

10839596

1370567_at

1380171_at

1396853_at

17765949

24174

5661636

5682398

5710366

5957866

6129387

6130170

6216575

6305161

6508882

A_44_P374610

A_44_P383088

A_64_P138008

GE1225349

GE21795

GO:0000165

GO:0001525

GO:0003012

GO:0003013

GO:0004930

GO:0004935

GO:0004938

GO:0005829

GO:0006940

GO:0007186

GO:0009986

GO:0016020

GO:0019229

GO:0023052

GO:0030154

GO:0030168

GO:0042060

GO:0043226

GO:0043231

GO:0043410

GO:0045666

GO:0048856

GO:0051379

GO:0060089

GO:0071875

ILMN_1376424

M32061_at

PH_rn_0003400

PH_rn_0022098

Participates

as a member of

ADRA2A,B,C [plasma membrane] (Rattus norvegicus)

Inferred From

ADRA2B [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_612514.2

ZINC - Investigational

ADA2B_RAT

ZINC - Metabolites

ADA2B_RAT

ZINC - World Drugs

ADA2B_RAT

ZINC - FDA approved

ADA2B_RAT

ZINC - Substances

ADA2B_RAT

Ensembl

ENSRNOP00000018584, ENSRNOT00000018584, ENSRNOG00000013887

ZINC target

P19328

ZINC - Biogenic

ADA2B_RAT

PRO

P19328

ZINC - Predictions - Purchasable

ADA2B_RAT

RGD

2057