H2O2 diffuses from the mitochondrial matrix to the cytosol

Stable Identifier
R-RNO-3779389
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
H2O2 diffuses from the mitochondrial matrix to the cytosol
Hydrogen peroxide is released from mitochondria at a rate that is dependent on the membrane potential (Boveris et al. 2006). Release of hydrogen peroxide from heart mitochondria is about 0.42 nmol/min/mg protein (Valdez and Boveris 2007).
Literature References
PubMed ID Title Journal Year
20170624 What are the sources of hydrogen peroxide production by heart mitochondria?

Kareyeva, AV, Grivennikova, VG, Vinogradov, AD

Biochim. Biophys. Acta 2010
16341777 ATP accelerates respiration of mitochondria from rat lung and suppresses their release of hydrogen peroxide

Carlson, DE, Fiedler, SM, Chiu, WC, Pumplin, DW, Scalea, TM, Ghavam, S

J. Bioenerg. Biomembr. 2005
17127374 Mitochondrial nitric oxide synthase, a voltage-dependent enzyme, is responsible for nitric oxide diffusion to cytosol

Boveris, A, Valdez, LB

Front. Biosci. 2007
16615992 Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol

Zaobornyj, T, Boveris, A, Valdez, LB, Bustamante, J

Biochim. Biophys. Acta 2006
Participants
Input
Output
Orthologous Events
H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)
Authored
May, B  (2013-06-27)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-27)
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