Interaction of NCAM-1 with Neurocan

Stable Identifier
R-RNO-375145
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of NCAM-1 with Neurocan
NCAM1 bind all major components of neurocan (N-terminal, central and C-terminal regions as well as CS chains), a brain-specific chondroitin sulfate proteoglycan. This molecule interferes with homophilic NCAM1 interactions and inhibits neuronal adhesion and neurite outgrowth.
Literature References
PubMed ID Title Journal Year
8910306 Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM

Retzler, C, Rauch, U, Gohring, W

J Biol Chem 1996
Participants
Input
Output
Orthologous Events
Interaction of NCAM1 with Neurocan (Homo sapiens)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2008-08-11)
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