Reactome | Ghost homologue of DOCK1 [cytosol]

Ghost homologue of DOCK1 [cytosol]

Stable Identifier

R-RNO-372654

Type

Genes and Transcripts [GenomeEncodedEntity]

Species

Rattus norvegicus

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Rattus norvegicus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
        
        Ghost homologue of DOCK1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by PTK6 (Rattus norvegicus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Rattus norvegicus)
      - Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
        
        Ghost homologue of DOCK1 [cytosol] (Rattus norvegicus)
- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by VEGF (Rattus norvegicus)
    - VEGFA-VEGFR2 Pathway (Rattus norvegicus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
        
        Ghost homologue of DOCK1 [cytosol] (Rattus norvegicus)

Participates

as a component of

CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)

Inferred From

DOCK1 [cytosol] (Homo sapiens)

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