Pyruvate (PYR) and a proton are transported from the cytosol into the mitochondrial matrix. While the rat transport proteins that mediate this uptake have not been identified, the transport process is specific, saturable, and competitively inhibitable, indicating a specific role for a membrane transport protein (Papa et al. 1971; Halestrup and Denton 1974; LaNoue and Schoolwerth 1985).
Denton, RM, Halestrap, AP
Meduri, B, Paradies, G, Papa, S, Francavilla, A
Schoolwerth, AC, LaNoue, KF
pyruvate transmembrane transporter activity of mitochondrial pyruvate carrier [mitochondrial inner membrane]
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