Cytosolic PYR is transported to the mitochondrial matrix

Stable Identifier
R-RNO-372347
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
Synonyms
PYR + H+ (cytosol) => PYR + H+ (mitochondrial matrix)
General
SVG |   | PPTX  | SBGN
Cytosolic PYR is transported to the mitochondrial matrix

Pyruvate (PYR) and a proton are transported from the cytosol into the mitochondrial matrix. While the rat transport proteins that mediate this uptake have not been identified, the transport process is specific, saturable, and competitively inhibitable, indicating a specific role for a membrane transport protein (Papa et al. 1971; Halestrup and Denton 1974; LaNoue and Schoolwerth 1985).

Literature References
PubMed ID Title Journal Year
4822737 Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

Denton, RM, Halestrap, AP

Biochem. J. 1974
11945601 The transport of pyruvate in rat liver mitochondria

Meduri, B, Paradies, G, Papa, S, Francavilla, A

FEBS Lett 1971
3888072 Transport of metabolic substrates in renal mitochondria

Schoolwerth, AC, LaNoue, KF

Annu Rev Physiol 1985
Participants
Catalyst Activity

pyruvate transmembrane transporter activity of mitochondrial pyruvate carrier [mitochondrial inner membrane]

Orthologous Events
Authored
Created
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