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Crkl [cytosol]
Stable Identifier
R-RNO-354384
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CRKL, Q5U2U2
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL binds CRK (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
CBL:CRKL binds RAPGEF1 (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates RAP1 and RAC1 (Rattus norvegicus)
CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
DOCK7 activates RAC1 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
RAPGEF1 activates RAP1 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
RAPGEF1 binds CRK,CRKL (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
MET receptor recycling (Rattus norvegicus)
GGA3 associates with activated MET receptor (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
p-FRS2:CRKL binds C3G (Rattus norvegicus)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Rattus norvegicus)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
Crk binds to the active PDGF receptor (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crkl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q5U2U2
Gene Names
Crkl
Reference Genes
BioGPS Gene:287942 Crkl
ENSEMBL:ENSRNOG00000001868
ENSEMBL:ENSRNOG00055003872
ENSEMBL:ENSRNOG00060011421
ENSEMBL:ENSRNOG00065008491
KEGG:rno:287942 Crkl
Monarch:287942 Crkl
NCBI Gene:287942 Crkl
UCSC:Q5U2U2 Crkl
Reference Transcript
RefSeq:NM_001008284.1 Crkl
RefSeq:XM_003751095.4 Crkl
Other Identifiers
10755751
1373879_at
1393402_at
1395605_at
17670810
287942
5793734
5821210
5959742
5988868
6050474
6082717
6232693
6232721
6293855
6422198
A_44_P166598
A_64_P156308
GE1245834
GE15946
GO:0001558
GO:0001568
GO:0001655
GO:0001764
GO:0001783
GO:0001784
GO:0001933
GO:0001934
GO:0002376
GO:0002685
GO:0003151
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0006629
GO:0007155
GO:0007163
GO:0007167
GO:0007283
GO:0007338
GO:0007389
GO:0007507
GO:0008284
GO:0008543
GO:0008584
GO:0009887
GO:0009952
GO:0010468
GO:0010629
GO:0012501
GO:0016358
GO:0021766
GO:0021987
GO:0022414
GO:0023052
GO:0030010
GO:0030154
GO:0031594
GO:0032991
GO:0033628
GO:0034330
GO:0035022
GO:0035591
GO:0035685
GO:0036211
GO:0038026
GO:0042802
GO:0043226
GO:0043410
GO:0045202
GO:0048384
GO:0048538
GO:0048856
GO:0048870
GO:0050773
GO:0050852
GO:0060017
GO:0060090
GO:0060326
GO:0061024
GO:0061629
GO:0070374
GO:0071466
GO:0071560
GO:0071774
GO:0086100
GO:0095500
GO:0098698
GO:0098749
GO:0098761
GO:0098890
GO:0160093
GO:1900026
GO:1903977
GO:1904393
GO:1904395
GO:1904888
GO:2000404
ILMN_1369034
PH_rn_0011996
rc_AI231488_at
Participates
as a member of
CRK, CRKL [cytosol] (Rattus norvegicus)
as a component of
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-Crkl [cytosol]
Inferred From
CRKL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001008285.1
,
XP_003751143.1
ENSEMBL
ENSRNOT00000002552
,
ENSRNOP00000002552
PRO
Q5U2U2
RGD
1308531
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