Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Cflar [cytosol]
Stable Identifier
R-RNO-3465357
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
FLIP(S), C0H5Y5
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
Dimerization of procaspase-8 (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
Cflar [cytosol] (Rattus norvegicus)
TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
Cflar [cytosol] (Rattus norvegicus)
TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
Cflar [cytosol] (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
CASP8 activity is inhibited (Rattus norvegicus)
FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
Cflar [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
Cflar [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:C0H5Y5
Gene Names
Cflar
Reference Genes
BioGPS Gene:117279 Cflar
ENSEMBL:ENSRNOG00000012473
ENSEMBL:ENSRNOG00000012473.6 Cflar
KEGG Gene (Rattus norvegicus):117279 Cflar
Monarch:117279 Cflar
NCBI Gene:117279 Cflar
Reference Transcript
RefSeq:XM_006244948.3 Cflar
RefSeq:XM_006244946.3 Cflar
RefSeq:XM_006244949.3 Cflar
RefSeq:XM_006244947.3 Cflar
RefSeq:NM_001033864.2 Cflar
Other Identifiers
10923580
117279
1379919_at
17859528
5691271
5776073
5886431
5959494
5960265
5974409
6212592
6216874
6220753
6434531
6438217
6519841
6612483
6731265
6734224
A_64_P109603
A_64_P109610
GE1215388
GO:0002020
GO:0003824
GO:0004197
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008047
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0031264
GO:0042981
GO:0043123
GO:0060544
GO:0097342
GO:0098772
GO:0140096
GO:1902042
GO:2001237
PH_rn_0010748
Participates
as an input of
FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
as a component of
DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
This entity regulates
Negatively
FAS-mediated dimerization of procaspase-8
(Rattus norvegicus)
TRAIL-mediated dimerization of procaspase-8
(Rattus norvegicus)
TNF-mediated dimerization of procaspase-8
(Rattus norvegicus)
Other forms of this molecule
Cflar [cytosol]
Cflar [cytosol]
Cflar [cytosol]
Cflar [cytosol]
Inferred From
FLIP(S) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006245009.1
,
XP_006245011.1
,
XP_006245008.1
,
NP_001029036.1
,
XP_006245010.1
Ensembl
ENSRNOP00000016730
,
ENSRNOG00000012473
,
ENSRNOT00000016730
RGD
620847
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text