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TP53 Tetramer [nucleoplasm]
Stable Identifier
R-RNO-3209194
Type
Complex
Species
Rattus norvegicus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
p53-Dependent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Dependent G1 DNA Damage Response (Rattus norvegicus)
Stabilization of p53 (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
G2/M DNA damage checkpoint (Rattus norvegicus)
ATR phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
DNA Damage/Telomere Stress Induced Senescence (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Oncogene Induced Senescence (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Oxidative Stress Induced Senescence (Rattus norvegicus)
MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Association with Co-factors (Rattus norvegicus)
BANP binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53:BANP [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Methylation (Rattus norvegicus)
EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Phosphorylation (Rattus norvegicus)
AMPK phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
ATR phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
AURKA phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
CDK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
NUAK1 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TAF1 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 binds HIPK1 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 binds STK11 and NUAK1 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53RK phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Expression (Rattus norvegicus)
TP53 forms homotetramers (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Transcriptional regulation by RUNX3 (Rattus norvegicus)
RUNX3 regulates CDKN1A transcription (Rattus norvegicus)
RUNX3 binds TP53 (Rattus norvegicus)
RUNX3:TP53 tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
PKR-mediated signaling (Rattus norvegicus)
p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 4
TP53 [nucleoplasm]
(Rattus norvegicus)
Participates
as an input of
RUNX3 binds TP53 (Rattus norvegicus)
p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)
BANP binds TP53 (Rattus norvegicus)
EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)
AURKA phosphorylates TP53 (Rattus norvegicus)
TP53 binds HIPK1 (Rattus norvegicus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
CDK5 phosphorylates TP53 (Rattus norvegicus)
TAF1 phosphorylates TP53 (Rattus norvegicus)
TP53 binds STK11 and NUAK1 (Rattus norvegicus)
MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
AMPK phosphorylates TP53 (Rattus norvegicus)
TP53RK phosphorylates TP53 (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
ATR phosphorylates TP53 (Rattus norvegicus)
as a component of
RUNX3:TP53 tetramer [nucleoplasm] (Rattus norvegicus)
TP53:BANP [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
as an output of
USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
TP53 forms homotetramers (Rattus norvegicus)
Inferred From
TP53 Tetramer [nucleoplasm]
(Homo sapiens)
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