Rab8A/13/14 Exchange GDP for GTP

Stable Identifier
R-RNO-2457808
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytoplasmic vesicle membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rab8A/13/14 Exchange GDP for GTP

Rab8A/13/14 release GDP and bind GTP (Sun et al. 2010, Ishikura et al. 2007). The reaction is enhanced by guanine nucleotide exchange factors (GEFs).

Literature References
PubMed ID Title Journal Year
17208202 Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

Klip, A, Ishikura, S, Bilan, PJ

Biochem Biophys Res Commun 2007
21041651 Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

Liu, Z, Klip, A, Sun, Y, Bilan, PJ

Proc Natl Acad Sci U S A 2010
Participants
Input
Output
Orthologous Events
RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)
Authored
May, B  (2012-08-21)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-08-28)
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