SeO3(2-) combines with GSH to form GSSeSG and GSSG

Stable Identifier
R-RNO-2408553
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
SeO3(2-) combines with GSH to form GSSeSG and GSSG

In the rat cytosol, selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism (Bjornstedt et al. 1992).

Literature References
PubMed ID Title Journal Year
1569062 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

Björnstedt, M, Holmgren, A, Kumar, S

J. Biol. Chem. 1992
Participants
Input
Output
Orthologous Events
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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