MeSeH is hydrolysed to H2Se by methylselenol demethylase

Stable Identifier
R-RNO-2408521
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MeSeH is hydrolysed to H2Se by methylselenol demethylase
In the rat cytosol, a yet to be identified enzyme with methylselenol demethylase (Msdm) activity is involved in the hydrolysis of methylselenol aka methaneselenol (MeSeH) into hydrogen selenide (H2Se) and methanol (Suzuki et al. 2007, Ohta and Suzuki 2008).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Suzuki, KT, Ohta, Y

Toxicol. Appl. Pharmacol. 2008
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Suzuki, N, Kurasaki, K

Biochim. Biophys. Acta 2007
Participants
Input
Output
Catalyst Activity

methylselenol demethylase activity of Msdm [cytosol]

Physical Entity
Msdm [cytosol] (Rattus norvegicus)
Activity
methylselenol demethylase activity (GO:0098608)
Orthologous Events
MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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