GSSeSG is reduced to GSSeH and GSH by Gsr

Stable Identifier
R-RNO-2408514
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GSSeSG is reduced to GSSeH and GSH by Gsr
In the rat cytosol, glutathione reductase (Gsr) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH) (Bjornstedt et al. 1992).
Literature References
PubMed ID Title Journal Year
1569062 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

Björnstedt, M, Kumar, S, Holmgren, A

J. Biol. Chem. 1992
Participants
Input
Output
Catalyst Activity

selenodiglutathione-disulfide reductase (NADPH) activity of 2xGsr-2:2xFAD [cytosol]

Physical Entity
2xGsr-2:2xFAD [cytosol] (Rattus norvegicus)
Activity
selenodiglutathione-disulfide reductase (NADPH) activity (GO:0098622)
Orthologous Events
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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