H2Se is methylated to MeSeH by H2Se methyltransferase

Stable Identifier
R-RNO-2408511
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
H2Se is methylated to MeSeH by H2Se methyltransferase
In the rat cytosol, a yet to be identified enzyme with hydrogen selenide methyltransferase (Hsemt) activity is involved in the methylation of hydrogen selenide (H2Se) into methylselenol aka methaneselenol (MeSeH) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy) (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Suzuki, KT, Ohta, Y

Toxicol. Appl. Pharmacol. 2008
14705 Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems

Ganther, HE, Hsieh, HS

Biochim. Biophys. Acta 1977
Participants
Input
Output
Catalyst Activity

hydrogen selenide methyltransferase activity of Hsemt [cytosol]

Physical Entity
Hsemt [cytosol] (Rattus norvegicus)
Activity
hydrogen selenide methyltransferase activity (GO:0098614)
Orthologous Events
H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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