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phospho-Mapk8 [nucleoplasm]
Stable Identifier
R-RNO-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
p-T,Y-MAPK8, P49185
Locations in the PathwayBrowser for interactor UniProt:P50232 SYT4
Expand all
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
phospho-Mapk8 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)
phospho-Mapk8 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P49185 Mapk8
Gene Names
Mapk8, Jnk1, Prkm8
Chain
chain:1-411
Reference Genes
BioGPS Gene:116554 Mapk8
KEGG:rno:116554 Mapk8
Monarch:116554 Mapk8
NCBI Gene:116554 Mapk8
UCSC:P49185 Mapk8
Reference Transcript
RefSeq:NM_053829.2 Mapk8
Participates
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
JNK1 [nucleoplasm]
JNK1 [cytosol]
Phospho-Jnk1 [cytosol]
Jnk1 [cytosol]
Mapk8 [cytosol]
phospho-Mapk8 [cytosol]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_446281.2
ZINC - Substances
MK08_RAT
ZINC target
P49185
PRO
P49185
GlyGen
P49185
RGD
621506
ZINC - Predictions - Purchasable
MK08_RAT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19493
2
Gria4 [endocytic vesicle membrane]
(R-RNO-416303)
Gria4 [plasma membrane]
(R-RNO-392229)
0.544
2
UniProt:P19491-3 GRIA2
0.544
2
UniProt:P50232 SYT4
0.508
5
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